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Stories Stories Health Intestinal bacterium Akkermansia curbs obesity

Intestinal bacterium Akkermansia curbs obesity

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Written by melody     July 28, 2014    
 
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A dominant and useful bacterium called Akkermansia muciniphila is present in the intestinal system of all humans, from babies to the elderly. This microorganism is found in the intestinal mucus layer that protects against intruders. Even more remarkable is that this bacterium has a favourable effect on the disrupted metabolism associated with obesity.

Prof. Patrice Cani from Brussels and Prof. Willem de Vos from Wageningen University, together with their colleagues, published these findings in the scientific journal Proceedings of the National Academy of Sciences (PNAS). They see potential in deployingAkkermansia bacteria to further understand and treat obesity and medical consequences.

Obesity and type 2 diabetes are both characterised by symptoms including inflammation, changes in the composition of the intestinal bacteria and the disruption of the natural barrier in the intestines. Ten years ago, researchers at the Laboratory of Microbiology at Wageningen University, part of Wageningen UR, discovered the bacteriumAkkermansia muciniphila (named after the Wageningen microbial ecologist Dr Antoon Akkermans, 1941-2006), which was able to grow in the mucus layer of the intestines. The bacteria were apparently present in large numbers in humans (and rodents) that were not overweight. Fewer were present in humans and rodents with inflammations or obesity. The microbiologists at Université Louvain in Brussels and their Wageningen colleagues wondered what the role of this bacterium could be.

Akkermansia curbs obesity

In the article that appeared on 13 May in the journal Proceedings of the National Academy of Sciences, the research team concluded that the bacteria are less frequent in mice with induced obesity and with type 2 (adult-onset) diabetes. Furthermore, administering rather indigestible fibres such as oligofructose, known for its advantageous effect on intestinal biota, resulted in a recovery of the Akkermansiapopulation in mice.

The presence of the bacteria strengthens the intestinal barrier and is also inversely correlated with weight increase (fat storage), inflammation reactions in fatty tissues and insulin resistance. However, is there also a causal relationship between the favourable developments and the occurrence of Akkermansia bacteria?

To check that, the researchers administered Akkermansia bacteria to ordinary mice on various diets. With a normal diet, no effect was noticed but in mice that became overweight as a result of a high-fat diet, the Akkermansia bacteria caused a reduction in fat development and associated metabolic defects, without affecting food intake. 

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Location

Epicentre
Wageningen UR
6708 PB Wageningen
Netherlands

Details

Author
Wageningen University and Research Centre
Contributor's Comment
Akkermansia is a genus in the phylum Verrucomicrobia (Bacteria). The genus was first proposed in 2004 by Muriel Derrien and others, with the type species Akkermansia muciniphila (gen. nov., sp. nov).
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